bbin,bbin官方平台

吴建平

来源:bbin官方平台 发布时间:2019.03.11 08:44


姓名:吴建平

性别:

出生年月:1968年11月

学位:博士

职称:bbin,教授

联系电话:18062552085

Emailbiojpwu@whut.edu.cn, biojpwu@gmail.com

教育经历:

1994/09 – 1997/07武汉同济医科大学,预防医学,博士

1991/09 – 1994/07武汉同济医科大学,预防医学,硕士

1986/09 – 1991/07武汉同济医科大学,环境医学,学士

研究经历:

2018/03至今bbin官方平台,bbin官方平台,教授

2012/03–2018/03Virginia Tech Carilion School of Medicine, Assistant Professor

2009/10–2012/03Washington University in St. Louis, Sr. Scientist

2003/07–2009/10University of Alabama at Birmingham, Research Associate

1999/07–2003/07Georgia State University, Post-Doc Research Associate

研究领域:

1)脑血管病:侧重于脑功能保护基础研究及药物研发;

2)中枢神经网络的代谢性调控与癫痫:难治性癫痫发病机制、抗癫痫药物筛选。

主要科研项目:

1)ITPKA/IP4与PI3K/AKT信号途径交互调控NBCs活性引发脑缺血再灌注迟发性神经元死亡机制研究”,主持, 国家自然科学基金(81870935) 2019~2023;

2)“神经药理基础与创新”,主持,bbin官方平台,2018年~2023;

代表性论文与专利:

1)Jia M#, Zhang Q#, Guo X, Liu R, Liu S, Cheng N, Wang YF, Campbell SL, Wu J. Na+/HCO3- co-transporter inhibitor S0859 attenuates global cerebral ischemia-reperfusion injury in gerbils hippocampal CA1 neurons. CNS & Neurological Disorders - Drug Targets 2022 (in press)

2)Zahra A, Wang YF, Wang Q, Wu J. Epilepsy and autism share frequent neurodevelopmental correlation. Behav Neurol. 2022 Apr 27; 2022:5893519. doi:10.1155/2022/5893519.

3)Zahra A, Du L, Jia M, Butt MU, Wang Q, Wang Y, Wu J. Prenatal exposure of citalopram elicits depression-like and anxiety-like behaviors and alteration of morphology and protein expression of medial prefrontal cortex in young adult mice. J Integr Neurosci. 2022 Mar 23;21(2):61. doi: 10.31083/j.jin2102061.

4)Sun L#, Liu R#, Yang, H, Yu T, Wu J*, Wang Q*. Characteristics of Epileptiform Spike-wave Discharges and Chronic Histopathology in Controlled Cortical Impact Model of Sprague-Dawley Rats. Neurochem Res. 2022 Feb 1. doi: 10.1007/s11064-022-03542-y.

5)Liu R, Sun L, Wang Y, Jia M, Wang Q, Cai X, Wu J. Double-edged Role of KNa Channels in Brain Tuning: Identifying Epileptogenic Network Micro-Macro Disconnection. Curr Neuropharmacol. 2021 Dec 14. 20(5): 916-928; doi: 10.2174/1570159X19666211215104829.

6)Du L, Zahra A, Jia M, Wang Q, Wu J. Understanding the Functional Expression of Na+-Coupled SLC4 Transporters in the Renal and Nervous Systems: A Review. Brain Sci. 2021 Sep 26;11(10):1276. doi: 10.3390/brainsci11101276.

7)Sun L, Shan W, Yang H, Liu R, Wu J* and Wang Q*. The Role of Neuro -inflammation in Post-traumatic Epilepsy. Front Neurol. 2021 May 28;12:646152. doi: 10.3389/fneur.2021.646152.

8)Lu M, Jia M, Wang Q, Guo Y, Li C, Ren B, Qian F, Wu J. The electrogenic of sodium bicarbonate cotransporter and its roles in the myocardial ischemia-reperfusion induced cardiac diseases. Life Sci. 2021 Apr 1;270:119153. doi: 10.1016/j.lfs.2021.119153.

9)Kong Z, Wang Y, Zhang Y, Shan W, Wu J, Wang Q. MicroRNA-126 promotes endothelial progenitor cell proliferation and migration ability via the Notch pathway. Cardiovasc Diagn Ther. 2020 Jun;10(3):490-499. doi: 10.21037/cdt-20-178.

10) Yang H, Shan W, Zhu F, Wu J, Wang Q. Ketone Bodies in Neurological Diseases: Focus on Neuroprotection and Underlying Mechanisms. Front Neurol. 2019 Jun 12;10:585. doi: 10.3389/fneur.2019.00585.

11) Fan JJ, Shan W, Wu J, Wang Q. Research progress of vagus nerve stimulation in the treatment of epilepsy. CNS Neurosci Ther. 2019 Nov;25(11):1222-1228. doi: 10.1111/cns.13209

12) Yang T, Zang DW, Shan W, Guo AC, Wu J, Wang YJ, Wang Q. Synthesis and Evaluations of Novel Apocynin Derivatives as Anti-Glioma Agents. Front Pharmacol. 2019 Sep 3;10:951. doi: 10.3389/fphar.2019.00951.

13) Zhu F, Shan W, Xu Q, Guo A, Wu J, Wang Q. Ketone Bodies Inhibit the Opening of Acid-Sensing Ion Channels (ASICs) in Rat Hippocampal Excitatory Neurons in vitro. Front Neurol. 2019 Mar 12;10:155. doi: 10.3389/fneur.2019.00155.

14) Martinez Pedro#, Wu J#, Yang CT, Liang HW, Xia XM, Lingle CJ.? Genetic deletion of SLO2.2 enhances itch sensing, abolishes Na+ activated K+ current, and increases action potential firing frequency in DRG neurons. Elife. 2015 Nov 11;4. pii: e10013. doi: 10.7554/eLife.10013

15) Wang W, Wu J, Bernard K, Bevensee MO and Kirk K. CFTR channel activation: constitutive mutants and allosteric modulation by phosphorylation. Proc Natl Acad Sci USA. 2010 Feb 23;107(8):3888-93. Epub 2010 Feb 3.

16) Wu J, McNicholas CM, Bevensee MO. PIP2 modulation electrogenic Na/bicarbonate cotransporter (NBCe1). Proc Natl Acad Sci USA. 2009 Aug 18;106(33):14150-5. Epub 2009 Aug 10.

17) Wu J, Hablitz JJ. Cooperative activation of D1 and D2 dopamine receptors enhances a hyperpolarization-activated inward current in layer I interneurons.J Neurosci. 2005 Jul 6;25(27):6322-8.

18) Wu J, Piao H, Rojas A, Wang R, Wang Y, Cui N, Shi Y, Chen F and Jiang C. ?Critical membrane helical domains and amino acid residues in gating Kir6.2 channels by intracellular ATP. J Cell Physiol. 2004 Jan;198(1):73-81

19) Wang X, Wu J, Li L, Chen F, Wang R and Jiang C. Hypercapnic acidosis activates KATP channels in vascular smooth muscles. ?Circ Res. 2003 Jun 13;92(11):1225-32

20) Wu J, Cui, N., Piao, H., Wang, Y., Xu, H., Mao, J. and Jiang, C. Allosteric modulation of the mouse Kir6.2 channel by intracellular H+ and ATP. ?J? Physiol. 2002 Sep 1;543(Pt 2):495-504

学术奖励及荣誉:

National Alliance for Research on Schizophrenia and Depression” ?Young Investigator Award (NARSD, 2006)


附件下载: