bbin,bbin官方平台

晏乐三

来源:bbin官方平台 发布时间:2021.04.30 09:55

姓名:晏乐三

性别

出生年月19857

学位博士

职称研究员

Emaillsyan@whut.edu.cn

教育经历

2003.09-2007.07 bbin官方平台,高分子材料与工程专业,学士

2007.09-2013.01 中国科学院长春应用化学研究所,高分子化学与物理,博士

工作经历

2013.02-2014.03 美国约翰霍普金斯大学,生物医学工程系,博士后

2014.04-2018.02 美国宾夕法尼亚大学,生物医学工程系,博士后

2018.03-2019.06 美国宾夕法尼亚大学,生物医学工程系,Research Associate

2019.09-至今 ????bbin官方平台,材料复合新技术国家重点实验室,研究员

科研概况

近年来从事生物可降解高分子材料的合成以及在药物传输,分子成像等方面的研究,在刺激响应性生物可降解高分子的设计与合成,生物医用高分子材料在铂类金属药物传输,聚合物囊泡的制备及蛋白的担载,以及位点特异性抗体-药物键合物方向都有深入系统的研究。作为主要研究人员参与了国家973计划,国家自然科学基金以及美国国立卫生院(NIH)重大基金等项目的研究。至今,在国际著名期刊上已发表SCI论文50余篇,其中第一作者及通讯作者文章共20篇。课题组与美国宾夕法尼亚大学、约翰霍普金斯大学、中科院长春应用化学研究所、北京化学所等国内外科研机构建立了良好的合作关系。

研究领域

1.?生物医用高分子的合成及其在药物传输中的应用

2.?聚合物纳米胶囊类蛋白载体的开发及生物医用

3.?纳米探针与分子成像

近期主要科研项目

1.????????国家自然科学基金青年项目,项目编号520032112021-2023

2.????????湖北省自然科学基金青年项目,项目编号:2020CFB4182020-2022

3.????????bbin官方平台海外人才引进科研启动项目,2019-2022

近期发表论文

  1. Lijun Luo#, Lesan Yan#, Ahmad Amirshaghaghi, Yulong Wei, Tianyan You, Sunil Singhal, Andrew Tsourkas*, Zhiliang Cheng*. Indocyanine Green-Coated Polycaprolactone Micelles for Fluorescence Imaging of Tumors. ACS applied bio materials 2020, 3 (4), 2344-2349??(共同一作)

  2. Lesan Yan, Lijun Luo, Ahmad Amirshaghaghi, Joann Miller, Cathy Meng, Tianyan You, Theresa M Busch, Andrew Tsourkas, Zhiliang Cheng*. Dextran-Benzoporphyrin Derivative (BPD) Coated Superparamagnetic Iron Oxide Nanoparticle (SPION) Micelles for T2-Weighted Magnetic Resonance Imaging and Photodynamic Therapy. Bioconjugate chemistry, 2019, 30 (11), 2974-2981

  3. Lesan Yan, Ahmad Amirshaghaghi, Dennis Huang, Joann Miller, Joel M. Stein, Theresa M. Busch, Zhiliang Cheng*, and Andrew Tsourkas*. Protoporphyrin IX (PpIX)-coated superparamagnetic iron oxide nanoparticle (SPION) nanoclusters for Magnetic Resonance Imaging and Photodynamic Therapy. Advanced Functional Materials. 2018, 28, 1707030.

  4. Bo Shi, Kexin Huang, Jianxun Ding, Weiguo Xu*, Yu Yang, Haiyan Liu*,Lesan Yan*, Xuesi Chen. Intracellularly Swollen Polypeptide Nanogel Assists Hepatoma Chemotherapy, Theranostics, 2017; 7(3):703-716.

  5. Lesan Yan, Joann Miller, Min Yuan, Jessica F. Liu, Theresa M. Busch, Andrew Tsourkas, and Zhiliang Cheng*. Improved Photodynamic Therapy Efficacy of Protoporphyrin IX Loaded Polymeric Micelles Using Erlotinib Pretreatment. Biomacromolecules,2017, 18 (6), 1836–1844.

  6. Haiqin Song, Xiang Kang, Jing Sun, Xiabin Jing, Zehua Wang, Lesan Yan*, Ruogu Qi* and Minhua Zheng*. Nanoparticles Delivery of Sterically Hindered Platinum (IV) Prodrugs Show over 100 Times Potency as Cisplatin upon Light Activation. Chemical Communications, 2016, 52, 2281-2283.

  7. Qiang Yang, Jing Cai, Si Sun, Xiang Kang, Jing Guo, Yapei Zhu, Lesan Yan*, Xiabin Jing and Zehua Wang*. Polymer Nanoparticle Delivery of Dichloroacetate and DACH-Pt to enhance antitumor efficacy and lower systemic toxicity. Biomaterials Science, 2016, 4, 661-669

  8. Lesan Yan, Huiquan Wang, Anqi Zhang, Calvin Zhao, Yongping Chen and Xingde Li*. Bright and Stable Near-Infrared Pluronic-Silica Nanoparticles as a Contrast Agent for in vivo Optical Imaging. Journal of Materials Chemistry B. 2016, 4, 5560-5566.

  9. Lesan Yan, Elizabeth Higbee, Andrew Tsourkas, Zhiliang Cheng*. A simple method for the synthesis of porous polymeric vesicles and their application as MR contrast agent. Journal of Materials Chemistry B, 2015, 3 (48), 9277-9284.

  10. Lesan Yan, Samuel H. Crayton, Jayesh P. Thawani, Ahmad Amirshaghaghi, Andrew Tsourkas and Zhiliang Cheng*. A pH-responsive drug delivery platform based on glycol chitosan-coated liposomes. Small, 2015, 11 (37), 4870-4874.






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